A Clinical Case of Scrub Typhus in the United States Forces Korea Patient with Eschar and Genetic Identification of Orientia tsutsugamushi Using Multiplex PCR-Based Next-Generation Sequencing

A Clinical Case of Scrub Typhus in the United States Forces Korea Patient with Eschar and Genetic Identification of Orientia tsutsugamushi Using Multiplex PCR-Based Next-Generation Sequencing

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An epidemiological investigation was conducted for a scrub typhus case reported in a U.S.Forces Korea military patient in the Republic of Korea in November 2018.The patient had a fever, maculopapular rash, and Antistatic Wipes an eschar.The full-length sequence of Orientia tsutsugamushi 56-kDa type-specific antigen (TSA) gene was obtained from eschar tissue by multiplex PCR-based Next Generation Sequencing for genetic identification.

Based on the 56-kDa Sweatshirts TSA gene, the O.tsutsugamushi aligned most closely with the Boryong strain.